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The third generation of IPT came along with Dr. Donato Pérez García, who learned the protocol from his father. By December of 1982, he introduced the intravenous use of insulin to patients receiving the treatment. Later that month Dr. Donato implemented the first modification of the administration procedure and patients began with the new routine. By 1986 the name “Insulin Potentiation Therapy” was given by Dr. Ayre. Today the name of this therapy is “Insulin Potentiation Therapy Low Dose” or IPTLD ® (a registered trademark) and it is comprised of a combination of the best developed protocols. Thousands of patients treated by three Donato generations of medical doctors till this day.